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Old 12-04-2009, 05:00 PM
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Default The FDA warns: Plavix and Prilosec should not be taken together

[11/17/2009]
FDA is alerting the public to new safety information concerning an interaction between clopidogrel (Plavix), an anti-clotting medication, and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to reduce stomach acid. New data show that when clopidogrel and omeprazole are taken together, the effectiveness of clopidogrel is reduced. Patients at risk for heart attacks or strokes who use clopidogrel to prevent blood clots will not get the full effect of this medicine if they are also taking omeprazole. The updated label for clopidogrel will contain details of new studies submitted by Sanofi-Aventis and Bristol-Myers Squibb, the manufacturer of Plavix (clopidogrel).
Omeprazole inhibits the drug metabolizing enzyme (CYP2C19) which is responsible for the conversion of clopidogrel into its active form (active metabolite). The new studies compared the amount of clopidogrel's active metabolite in the blood and its effect on platelets (anti-clotting effect) in people who took clopidogrel plus omeprazole versus those who took clopidogrel alone. A reduction in active metabolite levels of about 45% was found in people who received clopidogrel with omeprazole compared to those taking clopidogrel alone. The effect of clopidogrel on platelets was reduced by as much as 47% in people receiving clopidogrel and omeprazole together. These reductions were seen whether the drugs were given at the same time or 12 hours apart.

www.fda.gov/drugs
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Old 12-04-2009, 05:06 PM
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DG--That is great info to know and to pass along to as many people as possible!
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Old 12-04-2009, 09:51 PM
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ITA. I take Omeprazole, but have never taken Plavix. I do take garlic supplements (for a variety of reasons), and I hope there's no interaction there.
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Old 12-05-2009, 07:44 PM
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I wonder what drove the FDA to issue an alert now...this is not new information...
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